Fe3O4-loaded lipid perfluorooctylbromide nanoparticles as ultrasound contrast agents
10.3760/cma.j.issn.1004-4477.2011.07.030
- VernacularTitle:载Fe3O4全氟溴辛烷纳米粒增强超声显像的实验研究
- Author:
Ao LI
;
Zhigang WANG
;
Guoqing ZUO
;
Jinhong YU
;
Yuanyi ZHENG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Nanoparticles;
Perfluorooctylbromide;
Superparamagnetic iron oxides
- From:
Chinese Journal of Ultrasonography
2011;20(7):625-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the feasibility of the Fe3O4-loaded lipid perfluorooctylbromide nanoparticles (Fe3O4-PFOB) for enhanced ultrasound imaging.Methods The Fe3O4-PFOB nanoparticles,incubated with RAW264.7 macrophage cells,were monitored by microscope and ultrasound.Twelve SD rats were randomized into two groups,Fe3O4-PFOB group and PFOB group.Ultrasound imaging of rats' liver was performed before and after intravenous injection of the contrast agents.The liver echogenic intensity was quantified by DFY ultrasound quantified system analysis.Results Incubation of the Fe3O4-PFOB nanoparticles with macrophages resulted in the uptake of Fe3O4-PFOB by macrophages.Macrophages loaded with Fe3O4-PFOB exhibited enhanced echogenicity in vitro.In in vivo imaging,Fe3O4-PFOB produced better and prolonged ultrasound enhancement of rats' liver compared to PFOB nanoparticles.Conclusions Fe3O4-PFOB nanoparticles could enhance ultrasound imaging and may potentially serve as a multimodal probe for ultrasound,CT and MR imaging.
