Study of prostate specific antigen relevant parameters in prostate cancer by three-dimensional transrectal ultrasonography
10.3760/cma.j.issn.1004-4477.2011.07.017
- VernacularTitle:经直肠三维超声检测前列腺特异性抗原相关参数诊断前列腺癌的价值
- Author:
Chengzhong PENG
;
Xiaoming FAN
;
Xinman ZHANG
;
Tianan JIANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Prostatic neoplasms;
Prostatic hyperplasia;
Prostate-specific antigen
- From:
Chinese Journal of Ultrasonography
2011;20(7):594-597
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the utility of serum prostate specific antigen(PSA) density (PSAD),prostate antigen transition zone density(PSAT) and the ratio of free/total PSA with PSAD [(F/T)/PSAD] in the diagnosis of prostatic carcinoma (PCa) by three-dimensional ultrasonography.Methods Seventy-eight patients (serum prostate-specific antigen between 4-20 μg/L ) were involved.The prostatic volume and its transition zone volume were measured by three-dimensional ultrasonography.Then the relative parameters of PSA [PSAD,PSAT and (F/T)/PSAD] were calculated.Pathologic types were determined by using needle biopsy of prostate.Results Among them,27 patients were suffering from PCa,while the other 51 benign prostate hypertrophy (BPH).The difference of PSAD,PSAT and (F/T)/PSAD between PCa and BPH had arrived statistical significance (P<0.05).Proportions under the PCa curves were 0.736,0.760,0.800 respectively.Considering both sensitivity and specificity,a cutoff was recommanded:PSAD>0.20,PSAT>0.33,(F/T)/PSAD<0.8.Conclusions When the serum PSA level is between 4 μg/L and 20 μg/L,PSAD,PSAT and (F/T)/PSAD are of significant value to differentiate PCa from benign prostatic hyperplasia patients.The data are more reliable if prostatic volume are calculated by three-dimensional transrectal ultrasonography.
