Primary study of correlation between the time intensity parameters of contrast enhanced ultrasound and VEGF expression,microvessel density in hepatocellular carcinoma
10.3760/cma.j.issn.1004-4477.2011.04.011
- VernacularTitle:超声造影时问强度量化分析与肝细胞肝癌VEGF表达及微血管密度间关系的初步研究
- Author:
Yilin YANG
;
Yunyou DUAN
;
Ruijing YANG
;
Xi LIU
;
Jie LIU
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Carcinoma,hepatocellular;
Vascular endothelial growth factor;
Microvessel density
- From:
Chinese Journal of Ultrasonography
2011;20(4):307-310
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the correlations between vascular endothelial growth factor (VEGF) expression, microvessel density ( MVD) and time intensity parameters of contrast enhanced ultrasound in hepatocellular carcinoma (HCC). Methods Seventy-three patients of HCC were analyzed with time intensity curve of contrast enhanced ultrasound. VEGF and CD34 in different degree of differentiated HCC specimens were detected by immunohistochemistry. The correlations between VEGF, MVD and time intensity parameters were analyzed. Results Arrival time had no significant difference among different differentiated groups. However, the area under the curve, enhanced time and washout time had significant difference among different differentiated groups respectively ( P <0. 05). There was a positive correlation between VEGF expression and MVD in HCC. MVD was associated with enhanced time and the area under the curve ( r = - 0. 615,0. 563,respectively). The area under the curve,enhanced time and washout time of VEGF positive expression group had significant difference comparing to those of VEGF negative expression group ( P < 0. 05). Conclusions It was helpful to assess HCC differentiated degree with time intensity parameters of contrast enhanced ultrasound.
