The correlation between intraoperative contrast-enhanced ultrasound quantitative parameters and microvessel density of cerebral gliomas

VernacularTitle:脑胶质瘤超声造影定量参数与微血管密度的相关研究
Author: Jia WANG ; Yunyou DUAN ; Xi LIU ; Yu WANG ; Yongmei BA ; Liang WANG ; Guodong GAO ; Yilin YANG ; Tiesheng CAO
Publication Type:Journal Article
Keywords: Ultrasonography; Microbubbles; Glioma; Microvessel density
From: Chinese Journal of Ultrasonography 2011;20(4):294-297
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of intraoperative contrast-enhanced ultrasound(CEUS) in evaluating pathological grades of cerebral gliomas. Methods Intraoperative CEUS was performed in 33 patients of cerebral gliomas of different pathological grades. Real-time blood perfusion and enhance characteristics of these tumors were observed,quantitative parameters from the automatically derived time-intensity curve (TIC) were obtained, and compared with the tumor microvessel density (MVD) by immunostaining with anti-CD34. Results The time to peak was significantly shorter and the MVD was significantly higher in the high grade cerebral gliomas compared with the low grade ones ( P <0. 05). The time to peak was negatively correlated with the MVD by immunostaining (r = -0.79, P < 0. 05). Conclusions Intraoperative CEUS could be used to observe microvascular perfusion in real-time, and could indirectly reflect the information of MVD in cerebral gliomas, which is of help to grade cerebral gliomas and guide surgical resections.