Expression and significance of calcyclin binding protein in rat brain tissues after traumatic brain injury
10.3760/cma.i.issn.1001-8050.2011.06.020
- VernacularTitle:大鼠创伤性脑损伤后脑组织钙周期素结合蛋白的表达及意义
- Author:
Ming LIANG
;
Xiaosheng HE
;
Zhou FEI
;
Xiang ZHANG
;
Hongyu XU
;
Junli HUO
;
Xiaoyan CHEN
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Hippocampus;
Dentate gyrus;
Calcyclin binding protein
- From:
Chinese Journal of Trauma
2011;27(6):559-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of calcyclin binding protein (CacyBP)in the brain of rat model of traumatic brain injury(TBI).Methods Sixty 60 male SD rats were divided randomly into normal control group (n=10) and TBI group (n=50).The TBI model was created by using lateral head rotation device and subdivided into 6 h,24 h,72 h,7 d and 14 d group (10 rats per group).The expression and distribution of CacyBP in the rat brain was investigated immunohistochemically.The presence of the brown stained particles was considered aspositiveand lack of the stained particles agnegative. Results CacyBP was mainly distributed in the hippocampus,dentate gyrus and cortical neuron cytoplasm.Compared with the high level expression of CacyBP in the normal control group,the expression of CacyBP was decreased to the lowest in the rat brain at 6 h post TBI (P<0.01),became stronger gradually at 24 hours and recovered to normal at day 14,with no statistical difference compared with normal control group (P>0.05). Conclusion The lowest level expression of CacyBP after TBI indicates that CacyBP may play an important role in development of brain injury under effect of difierent mechanisms.
