Cognitive function changes in response to expression of glucocorticoid recepmr from rat hippocampus after traumatic brain injury
10.3760/cma.j.issn.1001-8050.2011.06.019
- VernacularTitle:TBI大鼠海马糖皮质激素受体表达变化对认知功能的影响
- Author:
Wei GAO
;
Xiaosheng HE
;
Xiang ZHANG
;
Zhou FEI
;
Hongyu XU
;
Junli HUO
;
Xiaoyan CHEN
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Hippocampus;
Receptors,gucocortiocid;
Cognitive dysfunction
- From:
Chinese Journal of Trauma
2011;27(6):555-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of glucocorticoid receptor(GR)expression in rat hippocampus on cognitive function after traumatic brain injury(TBI). Methods The TBI model wag established in rats.Then,immunohistochemistry and Western blot were used to detect the GR expression and evaluate its relation with cognitire dysfunction by Morris water maze. Results Expression of hippocampal GR was down-regulated 4-10 days after TBI.Morris water maze test showed significant impairment of the cognitive function in rats. Conclusion There is correlation between expression change of hippocampal GR and cognitive dysfunction.
