Correlation of senile hip fracture type with expressions of insulin-like growth factor and its binding proteins
10.3760/cma.j.issn.1001-8050.2011.06.015
- VernacularTitle:老年髋部骨折类型同胰岛素样生长因子及其结合蛋白表达的相关性研究
- Author:
Chaoge HANG
;
Haojie CHEN
;
Xiong YUE
;
Jia WANG
;
Gang XU
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
Hip fractures;
IGF-I;
IGFBP-3,4,5
- From:
Chinese Journal of Trauma
2011;27(6):541-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression difference of the insulin-like growth factor-I (IGF-I)and IGF-binding proteins-3,4,5(IGFBP-3,4,5)in the peripheral and local areas in senile hip fracture and discuss the correlation between the expression and the fracture types. Methods The study involved the senile patients (over 65 years) with hip fractures to compare the expressions of peripheral and local IGF-I and IGFBP-3,4,5 and observe the correlation between expression and fracture type.Results The serum and local specimens of 46 patients were collected,with lower level of BMD,IGF-I and IGFBP-3,5 in the intertrochanteric fracture group than the femoral neck fracture group(P<0.001)and with higher level of serum and local IGFBP-4 in the intertrochanteric fracture group than the femoral neck fracture group (P<0.001).Only local IGFBP-4 mRNA had positive correlation with serum markers (R=0.544,P<0.001). Conclusions The expression difference of IGF-I and IGFBP in the peripheral and local serum may be one of pathogenesis leading to different types of hip fractures.Except for the IGFBP-4,the other factors may affect the bone metabolism of the senile hip fractures through different regulatory mechanisms.
