Expressions of folkhead helix transcription factor 3 on CD4+ CD25+ regulatory T lymphocyte in intestinal mucosa in human immunodeficiency virus infected patients
10.3760/cma.j.issn.1000-6680.2011.05.012
- VernacularTitle:人类免疫缺陷病毒感染者肠黏膜组织中CD4+CD25+调节性T淋巴细胞及叉头状转录因子3的表达
- Author:
Lei SUN
;
Zhenwei LANG
;
Peng WANG
;
Ping LI
;
Hongxin ZHAO
;
Xiaoying TENG
;
Xingang ZHOU
;
Liang ZHANG
;
Bing SHEN
;
Mengdong LAN
- Publication Type:Journal Article
- Keywords:
HIV infections;
Intestinal mucosa;
CD4 positive T-lymphocytes;
T-lymphocytes,regulatory;
Transcription factors
- From:
Chinese Journal of Infectious Diseases
2011;29(5):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of CD4+ CD25+ regulatory T lymphocyte (Treg) and expressions of folkhead helix transcription factor 3 (FoxP3) in intestinal mucosa in human immunodeficiency virus (HIV) infected patients. Methods Twenty-one HIV infected patients and 17 control subjects without HIV infection were included in this study. The expression of FoxP3, which was considered as a specific marker of CD4+ CD25 + Treg, was detected in intestinal mucosa specimens from HIV infected patients by immunohistochemistry. Meanwhile, the in situ expression of CD4+ T lymphocyte was also determined by immunohistochemistry. The data were analyzed by t test. Results The positive labeling index of CD4+ T lymphocyte in intestinal mucosa was significantly lower in HIV infected patients compared to the controls (11. 56%±4. 44% vs 43. 49% ±8. 90% ,t=-11. 86,P<0. 01). The positive labeling index of FoxP3 in intestinal mucosa was also significantly lower in HIV infected patients compared to the controls (0.46% ± 0.20% vs 1. 18% ± 0. 44% ,t= - 5. 98,P<0.01). Conclusion The depletion of CD4+ CD25+ Treg is accompanied with the depletion of CD4 + T lymphocyte and the reduction of FoxP3 expression in intestinal mucosa of HIV infected patients.
