Relationship between-844T/C polymorphisms of Fas ligand gene promoter and fulminant hepatitis B
10.3760/cma.j.issn.1000-6680.2011.05.008
- VernacularTitle:Fas配体启动子区-844T/C单核苷酸多态性与重型乙型肝炎转归的关系
- Author:
Feng TANG
;
Xingxing HE
;
Ying CHANG
;
Jiayun ZHANG
;
Zhi CHEN
;
Jing WANG
;
Junshuai WANG
;
Pian LIU
;
Xuejun TANG
;
Jusheng LIN
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Polymorphisms,single nucleotide;
Ligands;
Gene type;
Promoter regions (genetics);
Hepatitis B surface antigens
- From:
Chinese Journal of Infectious Diseases
2011;29(5):286-291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between single nucleotide polymorphism (SNP) of Fas ligand (FasL) and fulminant hepatitis B in Han Chinese. Methods HBV infected subjects were enrolled in this case-control study, including 233 cases of inactive HBsAg carrier, 68 patients with fulminant hepatitis B,100 cases of spontaneous hepatitis B clearance, 102 patients with hepatitis B virus (HBV) related cirrhosis and 112 patients with HBV related primary hepatocellular carcinoma. The blood samples and clinical data were collected. FasL-844T/C polymorphisms of enrolled subjects were examined by TaqMan real time fluorescent genotyping polymerase chain reaction (RT-PCR). A adjusted odds ratios (OR)and 95% confidence intervals (CI)were calculated using the Logistic regression model. Results After adjusting the factors of gender and age, binary Logistic regression analyses indicated that the genotype frequencies of FasL-844 CC,CT,TT in inactive HBsAg carriers were 50. 64% ,39. 91% and 9. 44% respectively, and those in cases of fulminant hepatitis B were 79. 41%, 17. 65% and 2. 94%, respectively. The analysis also revealed that FasL-844CC genotype in inactive HBsAg carriers was high risk factor of developing fulminant hepatitis B (OR =4. 729,95%CI:0. 510 - 21. 282,P = 0. 043), while there were no statistic significances in other cases (P>0. 05). Conclusion The inactive HBsAg carriers harboring FasL-844CC may have greater susceptibility to fulminant hepatitis B, which need arouse high attention.
