The effects of endothelin, nitric oxide and vascular endothelial growth factor levels on the patients with with type 2 diabetic retinopathy
10.3760/cma.j.issn.1008-6315.2011.08.010
- VernacularTitle:血浆内皮素和一氧化氮以及血管内皮生长因子对2型糖尿病视网膜病变的影响
- Author:
Ying WANG
;
Yuan SUN
;
Jianfen WEI
;
Xiuping JIN
;
Dong CHEN
;
Naijun WU
;
Shaojie MA
;
Wei JIA
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Endothelin;
Nitric oxide;
Vascular endothelial growth factor
- From:
Clinical Medicine of China
2011;27(8):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of endothelin,nitric oxide and vascular endothelial growth factor level in patients with type 2 diabetic retinopathy (DR). Methods Eighty diabetes patients (53 with diabetic retinopathy and 27 without). Another 30 healthy volunteers were recruited as control. Plasma ET and VEGF levels were measured by enzyme-linked immunosorbent assay. NO levels were measured by nitrate reductase method. Results Plasma levels of ET were higher in patients with type 2 diabetes with DR (DR)(80. 68 ± 13.57) mg/L than (65. 33 ± 11.24) mg/L, (45.25 ±9. 06) mg/L, in control and in type 2 diabetes patients without DR (NDR) (Ps ＜ 0, 01 ). Plasna levels of NO in DR group (69. 82 ± 14. 89) μmol/L were higher than (37. 85 ±-9. 11 ) μmol'L, in control group,but lower than (77.52 ±± 18.56) μmol/L in NDR group (Ps ＜ 0. 05 ). Plasma levels of VEGF ( 110. 52 ± 25.65 ) μg/L in DR were significantly increased compared with control (82.42 ± 18. 47 ) μg/L, and NDR(97.55 ±25.61)μg/L, (Ps ＜0.05).Conclusion ET, NO and VEGF may be involved in the pathogenesis of type 2 diabetic retinopathy.
