Predicting value of HCY, LDL-C and carotid IMT for women with CAD
10.3760/cma.j.issn.1008-6315.2011.08.006
- VernacularTitle:同型半胱氨酸和低密度脂蛋白胆固醇与颈动脉内膜中层厚度对女性冠心病患者的预测价值
- Author:
Yuxia WANG
;
Xueqiang LI
;
Jiping ZHAO
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Low density lipoprotein cholesterin;
Carotid intima-media thickness;
Coronary artery disease;
Women
- From:
Clinical Medicine of China
2011;27(8):802-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the predicting value of homocysteine ( HCY), low density lipoprotein cholesterin (LDL-C) and carotid intima-media thickness (IMT) for women with coronary artery disease (CAD). Methods To choose 115 patients with CAD and 102 patients of non-CAD;Homocysteine, LDL-C and IMT were assayed respectively;comparison and correlation analysis were performed based on genders. Results The rates for hyperhomocysteinemia and High Lipoproteinaemia in female CAD patients are 59. 6% and 75.0%,respectively,while they are 69. 9% and 78.6% for male CAD patients,which are both remarkably higher than 23.0% ,26.7%, 22. 2% and 23.6% in non-CAD patients ( Ps ＜ 0. 05 ). ROC curve shows that the best diagnostic boundary point is 0.953 mm for female IMT and 1. 021 mm for male IMT. At the boundary point,the sensitivity,specificity,positive predictive value and negative predictive value are 83.7% ,91.4% ,95.7% and 63. 8% in female, much higher than 62.9%, 65.3%, 76.2% and 53.3% in male. Conclusion hyperhomocysteinemia, high lipoproteinaemia are the important risk factors for women with coronary artery disease;IMT might be used as the predictor of CAD, which have more advantages for female than for male patients.
