Genetic variants in the promoter of cyclooxygenase 2 interacting with Hp infection and the risk of esophageal cancer

VernacularTitle:环氧化酶-2启动子变异与幽门螺杆菌感染交互和食管癌发病风险的关系
Author: Zhi ZHANG ; Hongge WANG ; Wenguang SONG ; Zhaohuan YANG ; Hong CHEN ; Ruilin WANG ; Zhanzhao FU
Publication Type:Journal Article
Keywords: Cyclooxygenase-2; Esophageal cancer; Genetic variant; Single nucleotide polymorphism
From: Clinical Medicine of China 2011;27(7):751-753
CountryChina
Language:Chinese
Abstract: Objective To evaluate the association of COX2 genetic variants with the risk of esophageal cancer and the interaction of COX2 genetic variants with Hp infection. Methods A total of 119 patients with esophageal cancer and 238 frequency-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Odds ratios (OR) and 95% confidence intervals ( CI) were estimated by logistic regression. Results Case-control analysis showed an increased risk of developing esophageal cancer for 1195 GA(OR =2.69,95% CI= 1. 46-5. 14) and 1195AA ( OR = 2. 30,95% CI = 1.23-4. 89) genotype carriers,respectively, compared with non 1195 GG carriers. When stratified by Hp status, the significantly increased risk of esophageal cancer was found among Hp carrier with OR (95%CI) =2.74 (1.35-5.96) ,but not among Hp non-carriers. Conclusion Genetic polymorphism in COX2 promoter region may play an important role in esophageal cancer by Hp infection.