Genetic variants in the promoter of cyclooxygenase 2 interacting with Hp infection and the risk of esophageal cancer
10.3760/cma.j.issn.1008-6315.2011.07.028
- VernacularTitle:环氧化酶-2启动子变异与幽门螺杆菌感染交互和食管癌发病风险的关系
- Author:
Zhi ZHANG
;
Hongge WANG
;
Wenguang SONG
;
Zhaohuan YANG
;
Hong CHEN
;
Ruilin WANG
;
Zhanzhao FU
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase-2;
Esophageal cancer;
Genetic variant;
Single nucleotide polymorphism
- From:
Clinical Medicine of China
2011;27(7):751-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association of COX2 genetic variants with the risk of esophageal cancer and the interaction of COX2 genetic variants with Hp infection. Methods A total of 119 patients with esophageal cancer and 238 frequency-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Odds ratios (OR) and 95% confidence intervals ( CI) were estimated by logistic regression. Results Case-control analysis showed an increased risk of developing esophageal cancer for 1195 GA(OR =2.69,95% CI= 1. 46-5. 14) and 1195AA ( OR = 2. 30,95% CI = 1.23-4. 89) genotype carriers,respectively, compared with non 1195 GG carriers. When stratified by Hp status, the significantly increased risk of esophageal cancer was found among Hp carrier with OR (95%CI) =2.74 (1.35-5.96) ,but not among Hp non-carriers. Conclusion Genetic polymorphism in COX2 promoter region may play an important role in esophageal cancer by Hp infection.