Histocytic necrotizing lymphadenitis: a clinicopathological analysis
10.3760/cma.j.issn.1008-6315.2011.07.022
- VernacularTitle:组织细胞性坏死性淋巴结炎的临床病理分析
- Author:
Ya HE
;
Wenyan DING
- Publication Type:Journal Article
- Keywords:
Lymphadenitis;
Lymphoma
- From:
Clinical Medicine of China
2011;27(7):735-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the clinicopathological features of histiocytic necrotizing lymphadenitis ( HNL). Methods Routine lymph node biopsies of 10 HNL cases were reviewed and their immunophenotyping were performed using S-P immunohistochemical staining. Results Histologically, HNL had discrete or integrated nodules variable in size in the paracortex,expecially in the interfollicular area,which were full of proliferating pleomorphic histocytes,transformed lymphocytes,and karyorrhectic debris without infiltration of the neutrophils, plasma cells and/or eosinophils. Immunohistochemistry revealed CD45RO + for transformed lymphocytes,CD68 +for histiocytes.and CD20 +for lymphocytes in the residual germinal centers. Conclusion The presence of pleomorphic histiocytes, transformed T-cells, and karyor-rhectic debris in the biopsy of lymph nodes, together with the absence of neutrophils support the diagnosis of HNL.
