Significance of VEGF-C and CD34 expression in thyroid papillary cancer tissue

VernacularTitle:甲状腺乳头状腺癌中血管内皮生长因子-C和CD34的表达及其临床意义
Author: Yu HUANC ; Huasheng LIANG ; Yuhua ZHONG ; Song ZHAN
Publication Type:Journal Article
Keywords: Thyroid papillary caner; VEGF-C; CD34; Lympgatic vessel
From: Clinical Medicine of China 2011;27(7):694-696
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between VEGF-C,CD34 expression and thyroid papillary tumor tissue by combining assays of VEGF-C and CD34 in thyroid tumor tissue.Methods The expression of VEGF-C and CD34 were dectected by immunohistochemistry in 61 cases(thyroid papillary cancer 38.thyroid adenoma 23).Results VEGF-C level in thyroid papillary cancer(38.24±19.58)were significantly hisher than that in thyroid adenoma(16.49±9.25,P<0.01);CD34 in thyroid papillary cancer (23.68 ±9.07)/HP were higher than that in thyroid adenoma(18.70±6.34,t=4.9889,P<0.01).We found a significant relationship between the VEGF-C expression and cancerometastasis or tumor size(P<0.01;P<0.05).There was also a relationship between the CD34 expression and cancerometastasis or tumor size or age (P<0.01 or P<0.05).There Was positive relationship between the expression of VEGF-C and CD34(r=0.46.P<0.01).Conclusion It is suggested that combined detections of VEGF-C and CD34 may have important reference value on the differential diagnosis between thyroid papillary tumor tissue.