Clinical study on treating deep venous thrombosis of the low extremity by recombinant tissue type plasminogen activator after gynecological surgery
10.3760/cma.j.issn.1008-6315.2011.06.026
- VernacularTitle:重组组织型纤溶酶原激活剂治疗妇科盆腔术后下肢深静脉血栓形成的临床研究
- Author:
Xiuyin YE
;
Junda LIU
;
Huanxia LU
;
Wenyan LIAO
- Publication Type:Journal Article
- Keywords:
Gynecological surgery;
Deep venous thrombosis;
Thrombolytic therapy;
Recombinant tissue-type plasminogen activator
- From:
Clinical Medicine of China
2011;27(6):637-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect and safety of using recombinant tissue type plasminogen activator (rt-PA) in early lower extremity deep venous thrombosis (DVT) after gynecological surgeries. Methods Twenty-five cases with early DVT after gynecological operation were enrolled and randomly divided into two groups,contorl group (n = 13) and the rt-PA therapy group (n = 12). The patients from contorl group were treated with Low-Molecular-Weight Heparins Calcium 0. 4 ml/d alone, and the rt-PA group accepted rt-PA 100 mg i. v in addition to the Low-Molecular-Weight Heparins Calcium. The recanalization rates of lamb veins,prothrombin time (PT) ,bleeding event and other adverse complications were observed and evaluated at day seven. Results The recanalization rates of lamb veins were 91. 7% (11/12) and 53. 8 % (7/13) in rtPA and the control group respectively,which showed significant difference between each other (x2 = 15. 68, P <0. 01). One case had vaginal stump bleeding in each group but no other hemorrhage in both group,the difference of bleeding rates between two groups didn't reach statistically significance (x2 = 1. 48 ,P> 0. 05). Two patients with vaginal stump bleeding were healed by local hemostasis. Conclusion The usage of rt-PA could improve the recanalization rate of DVT after gynecological surgery. The rates of adverse complications, including vaginal stump bleeding,were extremly low.
