The suitable range of PT-INR for Chinese people with acute deep venous thrombosis treated by warfarin anticoagulation therapy
10.3760/cma.j.issn.1008-6315.2011.06.022
- VernacularTitle:华法林治疗急性下肢深静脉血栓形成患者凝血酶原-国际标准化比值国人适宜性有效值的初步探讨
- Author:
Xiaolei SUN
;
Yanzheng HE
;
Hong ZEN
;
Wu ZHONG
;
Sen SHI
;
Xiangyu ZHOU
;
Hui YANG
;
Yong LIU
- Publication Type:Journal Article
- Keywords:
Deep venous thrombosis;
Warfarin;
PT-INR;
Anticoagulation
- From:
Clinical Medicine of China
2011;27(6):626-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the suitable range of PT-INR for Chinese people with acute deep venous thrombosis (DVT) treated by warfarin anticoagulation therapy. Methods Eighty seven DVT patients with indications to warfarin anticoagulation therapy were enrolled into the study and divide into two groups randomly. Patients from group A (n=47) took warfarin to adjust the PT-INR to range 1.7-2. 5,and patients from group B (n =40) took warfarin to adjust the PT-INR to range 2. 0-3. 0. The therapeutic effectiveness and the incidence of bleeding complications were compared between two groups. Results Forty-six patients (46/47,98%) had limb swelling symptoms relief in group A with one exception,which was diagnosed as pelvic tumor by ultrasonography,CT and tumor markers examination later. No patient underwent bleeding in group A Thirty eight patients (38/40,93%) had limb swelling symptoms relief in group group B with two exceptions,of which one case had Cockett syndrome and the other one had unknown aetiology. The total effective rate of group B was 95% . As to the complications of this group,3 patients had slight gum and nasal mucous membrane bleeding, 1 patient developed gastrointestinal bleeding. No patients had pulmonary embolism in both groups. Conclusion For Chinese people,anticoagulation therapy of acute deep venous thrombosis to adjust the range of PT-INR to 1.7-2. 5, shows good effectiveness and significantly reduced bleeding complications.
