The blood pressure control effect of captopril sustained-release-tablets based combination antihypertensive therapy on hospitalized high-risk patients with hypertension in high altitude region
10.3760/cma.j.issn.1008-6315.2011.06.011
- VernacularTitle:高原地区以卡托普利缓释片为基础的联合降压治疗对高危高血压住院患者血压控制的影响
- Author:
Yuhua JIN
;
Zhanmei CHEN
;
Yin ZHANG
;
Lin WANG
;
Junjie JIANG
;
Lizhi WANG
;
Haijun CHEN
- Publication Type:Journal Article
- Keywords:
Altitude;
Essential hypertension;
Combination therapy
- From:
Clinical Medicine of China
2011;27(6):593-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the blood pressure control effect of captopril sustained-releasetablets based combination, antihypertensive therapy on hospitalized high-risk patients with hypertension in high altitude region. Methods According to the blood pressure,risk factors and combined target organ damage,331 hospitalized patients with essential hypertension were divided into 2 groups and accepted different treatment:low-risk group had monotherapy (n=102) , and night-risk group had captopril sustained-release-tablets based combination antihypertensive therapy (n =229). The discharge blood pressure,extent of SBP/DBP decrease and the compliance rate of discharge blood pressure of two groups were compared. Results The extent of SBP/DBP decrease in hight-risk group was significantly greater than low-risk group (SBP [36. 83 ± 22. 23] mm Hg vs.[28. 74 ±18.71] mm Hg,t=-3. 207,P <0. 05;DBP[22. 04±13. 57]mm Hg vs. [17. 98 ± 13.63] mm Hg,t =-2. 509, P < 0.05). The average discharge blood pressure in both groups reach the standard criterion, but no significant difference was observed between the two groups (SBP [125. 62 ± 14. 74] mm Hg vs. [122. 28 ±13.13]mmHg,t=-1. 962,P>0. 05;DBP[80. 67 ±9. 82]mm Hg vs. [78. 40 ±9. 97]mm Hg,t =-1.910,P > 0. 05). Furthermore we found no significant difference in the control rate of blood pressure between high-risk and low-risk group (72. 06% vs. 71. 57% , x2 = 0.928, P > 0. 05). Conclusion The captopril sustainedrelease-tablets based combination antihypertensive therapy is a reliable treatment in high-risk patients with hypertension from high altitude region,which shows satisfying blood pressure control rate.
