Expression and clinical significance of VEGF, ENS and MVD in atherosclerosis plaque of femoral artery in patients with atherosclerosis obliterans
10.3760/cma.j.issn.1008-6315.2011.06.007
- VernacularTitle:动脉硬化闭塞症患者股动脉粥样硬化斑块中血管内皮生长因子、内皮抑素、微血管密度的表达及意义
- Author:
Xin MU
;
Shaokui LIU
;
Xiaomei WANG
;
Jun HONG
;
Nan CHU
;
Shiyi CHEN
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Endostatin;
Microvessel density;
Arteriosclerosis obliterans
- From:
Clinical Medicine of China
2011;27(6):582-584
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expressions of VEGF,ENS, MVD and arteriosclerosis (AS) plaque in atherosclerosis obliterans (ASO) patients. Methods Immunohistochemical staining was used to determine the expression of VEGF, ENS and MVD value in the atherosclerosis plaque of ASO patients hospitalized from October 2007 to August 2010 in our hospital (n =30),and the femoral arterials of control were collected from 22 amputation after traumatic injury. Results The expressions of VEGF (2. 24 ±0.31 vs. 1.87 ±0.27,t =3.58),ENS (1.84 ±0.41 vs. 1. 56 ±0. 38, t =2.09) and MVD value (8.79 ±2.46 slip/HP vs. 6. 05 ±1.68 slip/HP, t =3.64) were significantly higher in the AS plaque of ASO patient than control (P <0.01 or P < 0. 05). We found positive correlations between the expression of VEGF, VEGF/ENS with MVD (r = 0. 391, P < 0. 01; r =0. 583, P < 0. 05) , while negative correlation between the expression of ENS with MVD (r=-0. 328,P <0. 05). Conclusion VEGF promotes the angiogenesis in atherosclerosis plaque,while ENS shows opposite effect The comprehensive performance of them is promoting angiogenesis.
