Effect of sodium ozagrel combined with cobamamide and pancreatic kininogenase on diabetic peripheral neuropathy
10.3760/cma.j.issn.1008-6315.2011.06.005
- VernacularTitle:奥扎格雷钠联合腺苷钴胺及胰激肽原酶肠溶片治疗糖尿病周围神经病变的疗效观察
- Author:
Yanping ZHAO
- Publication Type:Journal Article
- Keywords:
Sodium ozagrel;
Cobamamide;
Pancreatic kallidinogenase;
Diabetic peripheral neuropathy
- From:
Clinical Medicine of China
2011;27(6):575-577
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe curative effect of sodium ozagrel combined with cobamamide and pancreatic kininogenase in patients with diabetic peripheral neuropathy (DNP). Methods Seventy-two diabetes patients with DNP in our hospital from September, 2008 to September, 2010 were randomly divided into observation group and control group. All patients were treated with cobamamide by intramuscular injection and pancreatic kininogenase taken orally. In the observation group sodium ozagrel injection were added to the treatment used in the control group. Results After one course of treatment, the total effective rate in the observation group was 91. 7% (31/36),which was better than the control group (63. 9% ,23/36) (x =7. 6, P<0. 05). Motor nerve conduction velocity of median nerve before and after treatment was (42.9 ± 1.9)m/s and(45. 9 ± 3. 0) m/s in the observation group, and (42. 2 ± 1. 7) m/s and (43. 1 ± 2. 1) m/s in the control group. Motor nerve conduction velocity of peroneal nerve before and after treatment was (34. 9 ± 3. 9) m/s and (46. 1 ±3.0)m/s in the observation group, ,and (35. 6 ±3.4)m/s and(36. 8 ±2. 5)m/s in the control group;Sensory nerve conduction velocity of median nerve was (41.2 ±3.2) m/s and (48. 5 ±4.0) m/s in the observation group,and (41. 5 ±3. 8)m/s and(42.4 ±3. 6) m/s in the control group, sensory nerve conduction velocity of peroneal nerve was(35.4 ±3. 4) m/s and(44. 8 ± 3. 2) m/s in the observation group, and (35. 9 ± 4.4) m/s and(37. 6 ± 3. 3) m/s in the control group. The difference of nerve conduction velocity before and after treatment in the observation group reached the statistical significance(P<0. 05), whereas not significant in the control group (P > 0. 05). After treatment, the nerve conduction velocity in the observation group significant better than those in the control group (P < 0. 05). Conclusion The treatments of sodium ozagrel combined with cobamamide and pancreatic kininogenase in diabetic peripheral neuropathy is safe and effective.
