Protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rats
10.3760/cma.j.issn.1008-1372.2011.06.014
- VernacularTitle:复方尿囊素片对阿司匹林所致大鼠胃黏膜损伤的保护作用
- Author:
Yi FU
;
Xinyan ZHANG
;
Meihua CUI
;
Xianmin LIU
;
Fanghong MOU
- Publication Type:Journal Article
- Keywords:
Allantoin/PD;
Aspirin/AE;
Gastric mucosa/IN/DE;
COMPOUNDS(TCD);
Tablets
- From:
Journal of Chinese Physician
2011;13(6):772-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rat model. Methods Sixty healthy male Wistar rats were randomly divided into five groups: Ⅰ (injury group), Ⅱ (control group), Ⅲ (sucralfate protective group), Ⅳ (aluminium hydroxide protective group), and Ⅴ (aldioxa protective group). The three protective groups were treated with sucralfate, aluminium hydroxide and aldioxa tablets respectively before gastric mucosal injury was induced. Then the ulcer index (UI), epithelial damage scoring (EDS) were measured, and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope. Results The data of group Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ obtained were as follow: ulcer index: 42.13±6.22, 3.13±1.46, 8.63±3.48, 18.00±6.16, 8.00±3.17, respectively; epithelial damage scoring: 3.67±0.49, 1.25±0.45, 1.41±0.51, 2.42±0.79, 1.50±0.52, respectively. In comparison with injury group, the ulcer index and epithelial damage scoring of gastric mucosa in aldioxa protective group were significantly decreased. Conclusions The results revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosal injury induced by aspirin.
