The clinical significance of plasma resistin levels in patients with acute coronary syndrome
10.3760/cma.j.issn.1008-1372.2011.05.010
- VernacularTitle:急性冠脉综合征患者血浆抵抗素浓度变化的临床研究
- Author:
Lixia YANG
;
Jinsong LI
;
Feng QI
;
Xianmei WANG
;
Chuanming GUO
;
Guihua MIAO
;
Mingqiu LI
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome/PA/ME;
Resistin/ME;
Coronary vessels/PA
- From:
Journal of Chinese Physician
2011;13(5):611-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between plasma resistin levels and acute coronary syndrome. Methods Four hundred patients were divided into coronary heart disease (CHD) group（310）and control group（90）according to the coronary Angiography (CAG). And CHD group was divided into ACS subgroup（n＝217）and SAP subgroup（n＝93）according to the clinical information. 85 cases in CHD group were underwent 64-slice spiral computed tomography coronary artery imaging. The severity and extent of coronary lesions were analyzed by CAG and graded by means of Gensini coronary score system. Resistin level in plasma of all patients was determined by enzyme linked immunosorbent assay. Results Resistin levels in CHD group［(889.1±248.2)pg/ml］ were significant higher compared with the control group［(261.6±111.9)pg/ml］ (P＜0.05), and resistin levels in ACS subgroup［(1260.0±368.0)pg/ml］ were much higher than that in SAP subgroup［(518.3±128.4)pg/ml］ (P＜0.05). Conclusions The resistin levels of patients with acute coronary syndrome increased significantly and might be associated with the vulnerable plaque. Resistin levels and 64 slice spiral computed tomography coronary artery imaging can be used to detect the vulnerable plaque in CHD patients.
