Effects of Sheng Mai San on the level of cell factors induced by lipopolysaccharide in chronic liver failure rats
10.3760/cma.j.issn.1008-1372.2011.05.002
- VernacularTitle:生脉散对大肠杆菌脂多糖诱导慢性肝衰竭大鼠细胞因子水平的影响
- Author:
Wenjun XU
;
Xiaozhou ZHOU
;
Wenfeng MA
;
Xinfeng SUN
;
Qiaoguang HUANG
;
Daqiao ZHOU
- Publication Type:Journal Article
- Keywords:
SHENGMAI POWDERS/PD;
Lipopolysaccharides/AE;
Liver failure/ME/ZD;
Endotoxins/ME;
Tumor necrosis factor-alpha/ME;
Interleukin-1beta/ME;
Interleukin-6/ME;
Intercellular adhesion molecule-1/ME
- From:
Journal of Chinese Physician
2011;13(5):581-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the Sheng Mai San on the levels of cell factors induced by lipopolysaccharide in acute liver failure rats. Methods The models of chronic liver failure were constructed by injecting CCl4 in the abdomen of rats. The serum levels of lipopolysaccharide and cell factors were determined after treating with LPS and Sheng Mai San for 2 hours. Results The serum level of IL-6［(64.50±18.79)pg/ml vs (4.79±0.57)pg/ml］, ICAM-1［(25100.00±5258.85)pg/ml vs (4215.50±942.79)pg/ml］ and TNF-α［(17.55±2.39)pg/ml vs (10.92±5.02)pg/ml］ was increased by CCl4 (P＜0.05), but there is no effect on the serum level of LPS in rats ［(0.058±0.007)EU/ml vs (0.040±0.002)EU/ml,P＞0.05］. Sheng Mai San can significantly reduce the serum level of IL-6, ICAM-1 and TNF-α in rats with acute liver failure induced by CCl4 ［(17.20±3.12)pg/ml,(9490.00±2725.78)pg/ml,(3.00±1.00)pg/ml,P＜0.05］. After treating with LPS for 2 hours, the serum level of LPS, TNF-α, IL-6, ICAM-1 markedly increased ［(0.501±0.019)EU/ml,(19750.00±9655.17)pg/ml,(5615.00±490.50)pg/ml,(41000.00±589.88)pg/ml,P＜0.01］. Sheng Mai San could reduce the serum levels of LPS, TNF-α, IL-6, ICAM-1 and in rats with chronic liver failure (P＜0.01). Conclusions SD Rats in the state of chronic liver fail-ure, existing serious serum endotoxin, can induce the levels of cell factors by diversification inflammation reaction and. ShengMaiSan can regulating the levels of cell factors in rats with chronic liver failure.
