Preliminary establish of the puberty pathological aggression animal model
10.3760/cma.j.issn.1674-6554.2011.07.019
- VernacularTitle:青春期病理性攻击动物模型的初步构建
- Author:
Yuan QU
;
Li LEI
;
Guangcheng QIN
;
Lixue CHEN
;
Hua HU
- Publication Type:Journal Article
- Keywords:
Pathological aggression;
Puberty;
Animal model;
Behavior
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(7):630-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the preferable puberty pathological aggression animal model.Methods The experimental models were established towards puberty rats by frustration test of non-reward and instigation test.Rat models were tested for specificity using open-field test,saccharine test,elevated plus-maze(EPM)and olfactory sensibility.Results ①Compared with normal aggression(52.5±5.36)and control group(8.83±1.34)in total aggressive times,the pathological aggression group(101.17±2.85)increased significantly(P<0.01);②Some behavior items of each model group were moderately or hishly correlated to total score(r=0.379～0.929);③There was a significant difference between pathological aggression group and normal aggression group in the numbers of attack toward vulnerable-body regions,persistence attack after intruder displayed submissive and hish attack/threat ratios(P<0.01);④The pathological aggression group did not show depression,anxiety and olfactory disorder,except for space cognitive function(P>0.05).However,the normal aggression group displayed obvious depressive mood.Conclusion Each behavioral index matches the criteria of pathological aggression model.Meanwhile,it also excludes other factors of disturbing the specificity of the model.It suggests this model may be preferable puberty pathological aggression animal model.
