Effect of early comprehensive intervention on neuro-behavior development and serum S100B of neonates with hypoxic-ischemic encephalopathy
10.3760/cma.j.issn.1674-6554.2011.07.011
- VernacularTitle:早期综合干预对缺氧缺血性脑病新生儿神经行为发育及血清S100B水平的影响
- Author:
Lijuan CHEN
;
Guoyan YIN
;
Junli ZHAO
- Publication Type:Journal Article
- Keywords:
Early intervention;
Hypoxic ischemic encephalopathy;
S100B;
Mental developmental
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(7):608-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the early comprehensive intervention on neonatal hypoxic ischemic encephalopathy (HIE) effects and the biological mechanisms.Methods 120 cases of HIE were randomly divided into intervention group and control group.Under the basis of drug treatment,the intervention group were given the different perceptual stimuli,audiovisual stimulation,active and passive limb training early comprehensive intervention,the control group only to normal drug treatment.The mental development index(MDI) and psychomotor develo pmental index (PDI) were applied after 3,6,12,and 18 months.S100B protein levels were detected using enzyme immunoassay.Results MDI score in the intervention group with HIE,from the beginning of the 12 month,was higher than that in the control group,there was significant differences (12th month:(96.6±9.4)vs (86.8±9.5),P<0.01).PDI score from the beginning of the 6 month,was higher in the intervention group with HIE than that in the control group,there were significant differences (6th month:(91.6±9.2)vs (82.2±11.0),P<0.01).Serum S100B protein level has a tendency to fall for all HIE patients with the old growth.Born in two groups of serum S100B protein levels were higher in neonate period,but there was no difference(P>0.05).From the beginning of the 3rd month,serum S100B protein levels in the intervention group were reduced significandy,compared with the control group at each time point level(3rd month:(1.29±0.15)ng/L vs(1.40±0.14)ns/L;6th month:(1.06±0.21)ng/L vs(1.26±0.22)ng/L,P<0.01).Conclusion Early intervention can improve the mental and motor development of children with HIE,and serum S100B protein is involved in the mechanisms.
