The association study of Ghrelin gene polymorphisms with the susceptivity of schizophrenia in Chinese Han population
10.3760/cma.j.issn.1674-6554.2011.07.005
- VernacularTitle:中国汉族人群Ghrelin基因单核苷酸多态性与精神分裂症关联研究
- Author:
Yongfeng YANG
;
Wenqiang LI
;
Weihua YUE
;
Hongxing ZHANG
;
Xueqin SONG
;
Hongyan YU
;
Dai ZHANG
;
Ge YANG
;
Jingyuan ZHAO
;
Luxian LV
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Ghrelin(GHRL);
Single nucleotide polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(7):589-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential association of Ghrelin(GHRL)gene polymorphisms susceptible to schizophrenia by case-control study.Methods Six hundred and thirty-four patients,six hundred and six healthy control subjects were recruited.Four SNPs rs696217,rs26802,rs27647 and rs26311 were detected by the polymerase chain reaction-based-restriction fragment length polymorphism analysis.Results No significant differences in genotype or allele frequencies of the four SNPs were observed between schizophrenic patients and healthy controls (Pvalues of genotype frequencies were 0.649,0.944,0.410,0.826;P values of allele frequencies were 0.773,0.992,0.301,0.723).However,seven haplotypes(GAAG,GAGC,GAGG,GCGC,GCGG,TAGC,TAGG)showed significant differences in frequency between schizophrenic and control groups(P values were 0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).Conclusion These data suggest that the GHRL gene may not be associated with susceptibility to schizophrenia in the Chinese Han population.However,the haplotype of GA may be the susceptive factor of schizophrenia.
