Effect of duration of untreated psychosis on gray matter in untreated first-episode schizophrenia
10.3760/cma.j.issn.1674-6554.2011.07.003
- VernacularTitle:精神病未治疗期长短对首发精神分裂症脑灰质的影响
- Author:
Qinling WEI
;
Leijun LI
;
Zhongxing LUO
;
Zhuang KANG
;
Zili HAN
;
Jinbei ZHANG
- Publication Type:Journal Article
- Keywords:
Duration of untreated psychosis;
Schizophrenia;
Gray matter;
Magnetic resonance imaging;
Voxel-based morphometry
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(7):583-585
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of duration of untreated psychosis(DUP) and the gray matter volumes in patients with first-episode schizophrenia.Methods 39 patients with first-episode schizophrenia were divided into two groups according to DUP:long-DUP group and short-DUP group.All the subjects underwent T1 weighted magnetic resonance imaging.After transformed with MRIcro software,all the images underwent standardization,segmentation,modulation and smoothing with Statistical Parametric Mapping 5 (SPM5) software.The gray matter volumes of the two groups underwent two-sample t-test with a Voxel-based morphometry (VBM)using SPM5 software.Results Long-DUP schizophrenic patients presented significantly reduced GM volume in the left thalamus(MNI:-6,-16,2;cluster=141 voxels)and the left temporal lobe(MNI:-46,-58,-6;cluster=69 Voxels),compared with short-DUP schizophrenic patients.Conclusion Delayed DUP may increase the loss of gray matter in schizophrenia.
