Observation on the efficacy and safety of physical and psychological symptoms in the inpatients with alcohol dependence after Trazodone treatment
10.3760/cma.j.issn.1674-6554.2011.06.020
- VernacularTitle:盐酸曲唑酮治疗酒依赖戒断后心理及生理症状的临床研究
- Author:
Guishan WANG
;
Chuanzhi ZHANG
;
Lei GAO
;
Aiqin WANG
;
Qiuling WANG
;
Ning YAO
- Publication Type:Journal Article
- Keywords:
Trazodone;
Alcohol dependence;
Withdrawal;
The symptoms of physical and psychological;
Recovery drink
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(6):541-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of anxiety, depression, insomnia and other psychological and physical symptoms after trazodone treated in patients with alcohol dependence. Methods 100 patients whose met the inclusion and exclusion criteria were divided into trazodone group and the placebo group with a randomized, double-blind, placebo-controlled method. Each of the patients was oral trazodone, or placebo 3 times a day, each time a course of treatment was 8 weeks. Hamilton Anxiety Scale ( HAM A) , Hamilton Depression Rating Scale(HAMD) , Pittsburgh Sleep Quality Index(PSQI) , side effects scale (TESS) score and the necessary examinations were used to assess. Survey the re-drink situation after 1 year. Results 81 patients completed treatment, 19 patients were discharged or lost due to early treatment failure loss. In Trazodone group (41 cases) , the HAMA, HAMD and PSQI score before treatment and after treatment, total scores decreased gradually after 2 weeks of the three score and comfort dose group (40 cases) were the difference was statistically significant (P< 0. 05 ) ;recovery drink rate of trazodone group was significantly lower than the placebo group (24.4% vs 55. 0% , P<0. 05) after 1 year. After treatment, the side effects scale score difference was not statistically significant (P> 0. 05 ). Conclusion Improve trazodone treat alcohol dependence withdrawal anxiety, depression and insomnia effectively. Found no adverse drug reactions and the safety is high. Reduce the recovery drink.
