Anterior cingulate and amygdala volume changes in first-episode, medication naive females with major depressive disorder: a voxel-based morphometric MRI study

VernacularTitle:女性首发重性抑郁障碍患者脑扣带回和杏仁核的形态学研究
Author: Yanqing TANG ; Lingtao KONG ; Feng WU ; Guangrong XIE
Publication Type:Journal Article
Keywords: Major depressive disorder; Magnetic resonance imaging; Voxel-based morphometry
From: Chinese Journal of Behavioral Medicine and Brain Science 2011;20(6):525-527
CountryChina
Language:Chinese
Abstract: Objective To research the changes of regional gray matter volumes in first-episode, medication naive females with major depressive disorder. Methods Magnetic resonance imaging and voxel-based mor-phometry were used to compare regional gray matter volumes between 14 medication-naive female participants with a first episode of major depressive disorder ( MDD) ( age( 29. 5 ±6.8) years, number of education years(11.4 ± 2. 7) years, duration of iIIness(5.4 ±5. 2 ) months, H AMD score(27.6 ±5.5)) and 14 female healthy comparison participants (HC) (age(29.5 ±6.9)years,number of education years( 12. 2 ±3. 3)years,HAMD score(2. 1 ± 1.9)). Results Volumes of bilateral anterior cingulate cortex ( ACC) and right amygdala were significantly smaller in the MDD group than those in the HC group. Conclusion These results suggest that volume reductions in ACC and amygdala in females with MDD are present at illness onset.