Analysis of the correlation of expression of HIF-1α and VEGF-C in colon carcinoma

VernacularTitle:缺氧诱导因子-1α和血管内皮生长因子-C与结肠癌相关性分析
Author: Hongfei NI ; Meihua WANG ; Yaodong PAN ; Weixing ZHANG ; Li SHEN
Publication Type:Journal Article
Keywords: Colonic neoplasms; HIF-1α; VEGF-C
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(14):1908-1910
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of hypoxia inducible factor-1α(HIF-1α) and vascular endothelial growth factor C(VEGF-C) in colon carcinoma,and their relation with clinical pathological parameters and prognosis. Methods Immunohistochemistry was used to detect the expression of HIF-1α and VEGF-C in 65 tissues of colon carcinoma. Results In all cases,the expression of HIF-1α had a positive correlation with the expression of VEGF-C(r= 0.638,P＜0.01).The expressions of HIF-1α and VEGF-C had significant correlation with clinical stage and nodal metastasis(P＜0.05) ,but had no relationship with sex,age and tumor size(P＞0.05). Conclusion The expression of HIF-1α and VEGF-C was correlated with nodal metastasis, tumorigenesis and prognosis of colon/carcinoma.