Clinical observation on the curative effect of teprenone combined with esomeprazole for reflux esophagitis
10.3760/cma.j.issn.1008-6706.2011.13.015
- VernacularTitle:替普瑞酮联合埃索美拉唑治疗反流性食管炎的临床疗效观察
- Author:
Qiuyuan LI
;
Jiewu CHEN
;
Yusheng LI
;
Shengxin TANG
- Publication Type:Journal Article
- Keywords:
Esophagitis,peptic;
Teprenone;
Esomeprazol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(13):1757-1759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effect of Teprenone combined with esomeprazole for reflux esophagitis. Methods 96 cases of reflux esophagitis comfirmed by endoscope were obtained and divied into observation group and control group randomly. Both groups were offered with esomeprazole and motilium. Teprenone was added to the observation group and sucralfate was added to the control group. Clinical effective rate,healing rate,adverse reactions and one-year follow up were observed closely after the course of 8 weeks. Results The relief time of clinical symptom and total effective rate in the observation group were(9.3 ±3.5)d and 95.8% respectively,which were significantly higher than those in the control group(P ＜0.05). Endoscopic effective rate was 93.8% in observation group and 81.2% in control group respectively and statistically significant difference was observed (P ＜0. 05). Recurrence rate after one year in the observation group was 8. 3% ,which was significantly lower than in the control group (P ＜ 0.05). One case of headache and nausea occurred in both groups but no severe adverse reaction was observed. Conclusion Teprenone combined with esomeprazole were more effective and more likely to approach the complete cure for reflux esophagitis.
