Clinical study on teramcinoline combined with dexamethasone in teratment of the patients with the grado Ⅳ of thyriod associated pehthalmopathy

VernacularTitle:曲安奈德联合地塞米松治疗Ⅳ级甲状腺相关性眼病的临床研究
Author: Jian ZHANG ; Lixin SUN ; Piqing HU ; Jianping GAO ; Decheng YU ; Ling LI
Publication Type:Journal Article
Keywords: Graves ophthalmopathy; Triamcinolone; Dexamethasone
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(13):1755-1756
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of triamcinolone orbital injection combined with dexamethasone in treatment of the patients with the grade Ⅳ of thyriod associated ophthalmopathy. Methods NOSPEVS Ⅳ grade of 90 patients were randomly divided into three groups,Group A,orbital injection of triamcinolone combind with dexamethasone, Croup B,simple injection of triamcinolone,Group C,oral prednisone therapy for half a year. To review each record of visual acuity intraocular pressure palpebral fissure size, upper eyelid drop late exophthalmos eye movement and so on every 4 weeks and follow-up for one year. Results Group A and group B of exophthalmos and eye movement improved obviously,however,Group C with poor efficacy and more side effects,and Group A in 3 groups was the fastest with least number of injections and which improved eye symptons significantly with fewer complications. Conclusion Orbital injection of triamcinolone combined with dexamethasone could be more rapid and effective than a simple injection of triamcinolone or oral prednisone to improve symptoms and signs in thyroid ophthalmopathy.