Significance of total bilirubin/albumin in predicting bilirubin neurotoxicity
10.3760/cma.j.issn.1673-4904.2011.21.003
- VernacularTitle:新生儿总胆红素与白蛋白比值对预测胆红素神经毒性的临床意义
- Author:
Qing CHEN
;
Weidong SU
;
Erli QU
;
Yudan HUANG
;
Xiurui DENG
- Publication Type:Journal Article
- Keywords:
Infant,newborn;
Evoked potentials,auditory,brain stem;
Serum albumin;
Total bilirubin;
Bilirubin neurotoxicity
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(21):7-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of total bilirubin/albumin in predicting bilirubin neurotoxicity.Methods Eighty-three cases with hyperbilirubinemia who treated from May 2007 to August 2010 were selected,the serum total bilirubin and albumin were detected and total bilirubin/albumin was calculated.According to brainstem auditory evoked potential(BAEP)results,the patients were divided into normal BAEP group and abnormal BAEP group and compared.Results There were 27 cases of abnormal BAEP group and 56 cases of normal BAEP group.Total bilirubin and total bilirubin/albumin in abnormal BAEP group were higher than those in normal BAEP group[(356.50±59.23)μmol/L vs.(318.70±55.12)μmol/L,(5.02±0.49)×10-3 vs.(4.56±0.43)×10-3],the differences were significant (P<0.05).Multiple regression analysis showed:abnormal BAEP was closely related to total bilirubin/albumin(r=0.72,P<0.05),whih abnormal BAEP was not obviously related to total bilirubin(r=0.19,P>0.05).Conclusion Total bilirubin/albumin can reflect serum unconjugated bilirubin level of neonatus with hyperbilirubinemia better than total bilirubin,and it can can be taken as one index to evaluate the risk factors of bilirubin neurotoxicity.
