The observation of clinical efficacy and adverse reactions of three dimensional-conformal radiotherapy combined with oral capecitabine in the treatment of stage Ⅱ, Ⅲrectal cancer after operation
10.3760/cma.j.issn.1673-4904.2011.19.007
- VernacularTitle:三维适形放射治疗同步口服卡培他滨治疗Ⅱ、Ⅲ期直肠癌术后的临床疗效及不良反应观察
- Author:
Haiyan LIU
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Radiotherapy,computer-assisted;
Antineoplastic combined chemotherapy protocols;
Capecitabine
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(19):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and adverse drug reactions of three dimensional-conformal radiotherapy combined with oral capecitabine in the treatment of stage Ⅱ , Ⅲ rectal cancer after operation. Methods Sixty-three patients of stage Ⅱ ,Ⅲ rectal eancer after operation with informed consent were divided into two groups by random digits table, 33 cases of observation group were treated by three dimensional-conformal radiotherapy combined with oral capecitabine, 30 cases of control group were treated by three dimensional-conformal radiotherapy only. Results The total effective rate in observation group was 84.8% (28/33), it was higher than that in control group [63.3% (19/30)], the difference between the two groups was statistically significant (P < 0.05). The occurrence rate of adverse reactions in two groups were compared, the difference was not statistically significant [57.6%(19/33) vs.50.0% (15/30)] (P>0.05). Conclusion Three dimensional-conformal radiotherapy combined with oral capecitabine in the treatment of stage Ⅱ,Ⅲrectal cancer after operation has satisfactory effect and acceptable adverse reaction, it is worth generalizing and applying.
