Pinaverium bromide combined with bifid triple viable and doxepin therapy in diarrhea-dominant irritable bowel syndrome
10.3760/cma.j.issn.1673-4904.2011.19.001
- VernacularTitle:匹维溴铵联合双歧杆菌三联活菌和多塞平治疗腹泻型肠易激综合征的疗效分析
- Author:
Rong WU
;
Jianmin SI
;
Kan WANG
;
Shujie CHEN
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Drug therapy,combination;
Dianhea;
Probiotics
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(19):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of stomach intestine power regulator, intestinal microecology preparation and tricyclic antidepressant treatment in irritable bowel syndrome (IBS), and to investigate its pathological mechanism. Methods From November 2006 to November 2010, 103 patients with diarrhea-dominant IBS (D-IBS), who fulfilled the Rome Ⅱ criteria and were excluded from organic disease by entewscope were divided into pinaverium bromide group (26 cases), pinaverium bromide + bifid triple viable group (28 cases), pinaverium bromide + doxepin group (25 cases) and pinaverium bromide +bifid triple viable + doxepin group(24 cases ) by random digits table. The symptom grade, intestinal flora and SCL-90 was tested before treatment and 4 weeks after treatment. Results The total effective rate of pinaverium bromide + bifid triple viable + doxepin group was 83.33%(20/24), significant higher than that in pinaverium bromide group [65.38%(17/26)], pinaverium bromide + bifid triple viable group [71.43%(20/28)], pinaverium bromide + doxepin group [68.00% ( 17/25 )] (P < 0.05 ). Five kinds of intestinal flora and psychiatric symptoms were improved in the four groups, and those in pinaverium bromide + bifid triple viable + doxepin group improved significantly. Conclusions To interfere the correlation factor of IBS can have better efficacy. There is a close relation between brain and gut in patients with IBS, which may be involved in the pathogenesis of IBS.
