Management value of high-risk human papilloma virus detectionin the women with atypical squamous cell of undetermined significance and low grade squamous intraepitheliallesion of thin prep liquid-based cytology
10.3760/cma.j.issn.1673-4904.2011.18.011
- VernacularTitle:高危型人乳头瘤病毒检测对细胞学结果为意义不明的非典型鳞状细胞和低度鳞状上皮内病变的管理价值
- Author:
Yinmin ZHANG
;
Xiuqin WANG
;
Fengying MIAO
;
Haiyan XING
- Publication Type:Journal Article
- Keywords:
Human papilloma virus;
Atypical squamous cell of undetermined significance;
Low grade squamous intraepithelial lesion
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(18):27-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the significance of high-risk human papilloma virus ( HR-HPV) detection by hybrid capture 2 (Hc-2) in managing the women with atypical squamous cell of undetermined significance (ASCIIS) and low grade squamous intraepithelial lesion (LSIL) of thin prep liquid-based cytology (TCT). Methods One hundred and seventy-eight women with ASCUS and 108 women with LSIL were studied. The infection of HR-HPV in the women was analyzed. And sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were used to evaluate the significance of HR-HPV detection by Hc-2 in managing the women with ASCUS and LSIL of TCT. Results Sensitivity,specificity, PPV and NPV of HR-HPV DNA detection by Hc-2 in screening CIN II or above in ASCUS were 89.83% (53/59),53.78% (64/119), 49.07% (53/108), 91.43% (64/70) respectively,and in LSIL were 97.62%(41/42),22.73%(15/66), 44.57%(41/92), 93.75%( 15/16) respectively. Conclusion HR-HPV detection by Hc-2 is an effective measure in managing the women with ASCUS and LSIL of TCT.
