Research of coagulation function changes in newborn hemolytic disease
10.3760/cma.j.issn.1673-4904.2011.18.007
- VernacularTitle:新生儿溶血病凝血功能变化的研究
- Author:
Haiyan CAI
;
Caiyun GAO
;
Min WANG
;
Aixia YAN
;
Shuzhong WANG
;
Yuyan YANG
- Publication Type:Journal Article
- Keywords:
Erythroblastosis,fetal;
Blood coagulation;
Platelet count
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(18):16-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance and coagulation function changes in newborn hemolytic disease. Method The newborn hemolytic disease ( 60 cases, hemolytic disease group ), non-hemolytic hyperbilirubinemia (60 cases, non-hemolytic hyperbilirubinemia group) and normal newborn (60 cases,control group) were selected as the study subjects, the prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured, and the blood platelet count at the same time was detected. Results PT and APTT in hemolytic disease group were higher than those in non-hemolytic hyperbilirubinemia group[(28.79 ?.21) s vs. (18.98?.41) s and (58.52?.13) s vs. (47.26?.81) s], and they were apparently higher than those in control group [(13.81 ?1.83) s and (38.10 ?3.00) s], the difference had statistic significance (P<0.05). There was no statistic significance to detect the blood platelet count (P> 0.05). Conclusions The newborn hemolytic disease has the bleeding tendency, and the bleeding tendency has no relationship with the quantity of the blood platelet, but relates to the extension of PT and APTT. The more serious the case is, the more obvious the PT and APTT rise. PT and APTT can be as the detection index and evaluating effect of the newborn hemolytic disease coagulation function.
