Clinical study of laparoscopic conservative surgery combined with medicine on prevention of persistent ectopic pregnancy
10.3760/cma.j.issn.1673-4904.2011.18.003
- VernacularTitle:腹腔镜保守性手术联合药物防治输卵管妊娠后持续性异位妊娠的临床研究
- Author:
Xiaohong ZOU
;
Li LIANG
;
Qiyi ZHANG
- Publication Type:Journal Article
- Keywords:
Methotrexate;
Mifepristone;
Laparoscopes;
Pregnancy,ectopic
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(18):6-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of methotrexate combined with mifepristone prophylaxis for persistent ectopic pregnancy (PEP) after laparoscopic conservative surgery. Methods One hundred and twenty cases of tubal pregnancy were randomly divided into two groups by admission number, the study group (60 cases) were treated by mifepristone before laparoscopic conservative surgery and methotrexate combined with mifepristone after laparoscopic conservative surgery, but the control group (60 cases) were treated by laparoscopic conservative surgery, the bleeding was observated in the surgery,concentration of β-human chorionic gonadotrop ( β-hCG) was detected before operation and 1,3,7,12 d after operation. Results There were significant differences in β-hCG after operation 3,7,12 d between two groups(P<0.05). The bleeding was (21.8 ?.2) ml in study group,and (38.1 ?3.1) ml in control group, there was significant difference between two groups (P<0.05). In study group, the incidence of PEP was 0, and 3.33%(2/60) in control group. Conclusion Preoperative mifepristone and postoperative mifepristone combined with methotrexate in preventing PEP after laparoscopic conservative surgery is efficacy, and it can be chosen in clinic.
