The expression of p53 and heat shock protein 70 in gastrointestinal stromal tumors and its sigulficance

VernacularTitle:p53和热休克蛋白70在胃肠道间质瘤中的表达及意义
Author: Wanchuan WANG
Publication Type:Journal Article
Keywords: Gastrointestinal stromal tumors; Genes,p53; Heat-shock proteins; Immunohistochemistry
From: Chinese Journal of Postgraduates of Medicine 2011;34(17):18-21
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the expression of p53,heat shock protein 70(HSP70)and clinieopathologie eharacteristies in gastrointestinal stromal tumor(GIST),and the correlation between p53 and HSP70 expression.Methods p53 and HSP70 expression of 48 cases with GIST was detected by immunohistechemieal SP method.Analyzed the correlation between p53 and HSP70 expression.Results Among 48 cases with GIST,the positive rate for p53 and HSP70 were 60.42%(29/48) and 64.58%(31/48)There was no significant difference in the gender,age of patients.localization of tumor (P>0.05).but there was significant difference in the histological grade (P<005).There was positive correlation between the expression of p53 and HSP70(X2=4.075,P<0.05).Conclusions The positive rate of p53 and HSP70 in GIST is high,especially in hish risk patients.The expressions of p53 and HSP70 play an important role in the pathogenesis and development of GIST,which may be used as an objective parameter for distinguishing malignant GIST from benign cases.