The expression of cyclooxygenase-2 in breast cancer tissues and its clinicopathological significance
10.3760/cma.j.issn.1673-4904.2011.17.001
- VernacularTitle:环氧合酶-2在乳腺癌组织中的表达及其临床病理意义
- Author:
Hui HAN
;
Wenxin ZHAO
;
Shunguo LIN
;
Chunsen XU
;
Yinghong YANG
;
Yuhui ZHENG
;
Jianping HUANG
- Publication Type:Journal Article
- Keywords:
Epoxide hydrolases;
Breast neoplasms;
Gene expression
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(17):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of cyclooxygenase-2(COX-2)in breast cancer tissues,as well as the relationship between COX-2 and the clinicopathological features.Method The expression of COX-2 was detected in 60 cases of breast cancer tissues and 20 cases of breast normal tissues by using immunohistochemistry,and combined with clinicopathological information for analysis.Results The COX-2 expression rate was 65.0%(39/60)in breast cancer tissues and 10.0%(2/20)in breast normal tissues respectively.There was statistic difference between the two(P<0.01).The over expression of COX-2 was significantly correlated with TNM stages,lymphatic metastasis and the expression of epidermal growuth factor receptor-2(C-erbB-2)(P<0.05 or<0.01).Conclusion The expression of COX-2 in breast cancer tissues is significantly higher,which might play a fairly important role in tumorigenesis and progression of breast cancer.
