Effects of transient intensive insulin treatment on free fatty acid in newly diagnosed type 2 diabetic patients
10.3760/cma.j.issn.1673-4904.2011.16.009
- VernacularTitle:短期胰岛素强化治疗对初发2型糖尿病游离脂肪酸的影响
- Author:
Yingjiu ZHAI
;
Mingxi FANG
;
Siyuan FENG
;
Qi FANG
;
Yanping YANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Fatty acids,nonesterified;
Intensive insulin treatment
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(16):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of transient intensive insulin treatment on the serum free fatty acid (FFA) in newly diagnosed type 2 diabetic patients.Methods Sixty-four newly diagnosed type 2 diabetic patients were treated with transient intensive insulin.The fasting plasma glucose (FPG),2 hours post-prandial glucose (2hPG),lipid,fastin insulin (FINS),and serum FFA was examined hefore and after treatment.Results The levels of FPG,2hPG,total cholesterol (TC),triglycerides (TG),low density lipoproteins cholesterol (LDL-C),FFA and HOMA-IR after treatment were (9.68 ± 2.02) mmol/L,(12.77 ± 1.35) mmol/L,(4.26 ± 1.07) mmol/L,(1.52 ± 0.58) mmol/L,(2.50 ±0.75) mmol/L,(435.84 ± 190.94) μmol/L,0.51 ± 0.62,and they decreased obviously compared with those before treatment [(14.66 ± 3.50) mmol/L,(17.43 ±4.89) mmol/L,(5.03 ±0.94) mmol/L,(2.05 ± 1.42) mmol/L,(2.91 ±0.78) mmol/L,(586.68 ±229.45)μmol/L,0.65 ± 0.89](P＜0.05).The level of HOMA-β increased obviously (2.70 ± 0.83 vs.1.74 ± 1.04)(P＜0.05).The increase of HOMA-β and the decrease of HOMA-IR was positively correlated with the decrease of FFA.Conclusion The transient intensive insulin treatment can evidently decrease the level of FFA that can improve beta-cell function and relieve insulin resistance in newly diagnosed type 2 diabetic patients.
