Study on the association between sex hormone-binding globulin and newly diagnosed type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2011.16.006
- VernacularTitle:性激素结合球蛋白与新诊断2型糖尿病关系的初步探讨
- Author:
Yuhuan WANG
;
Lili YAN
;
Min ZHANG
;
Junhong WANG
;
Chunhong ZHANG
;
Jing ZHANG
;
Peng DONG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Sex hormone-binding globulin;
Hemoglobin A,glycosylated;
Insulin resistance
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(16):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible mechanism of sex hormone-binding globulin (SHBG) in diabetes mellitus by detecting the level of serum SHBG in patients with newly diagnosed type 2 diabetes mellitus (T2DM),and analyze the correlation between serum SHBG and insulin resistance.Methods SHBG levels were determined by enzyme linked immunosorbent assay (ELISA) in 30 normal controls (control group) and 60 newly diagnosed T2DM patients(T2DM group).HOMA-IR was calculated.Results The levels of serum SHBG in T2DM group were significantly lower than those in control group [(22.6 ±9.7)mmol/L vs.43.1 ±11.9) mmol/L,P <0.05]; SHBG level was negatively correlated with triglyceride(TG),low density hpoprotein cholesterol(LDL-C),fasting insulin(FINS),hemoglobintHbA1c) and lgHOMA-IR (r =-0.351,-0.361,-0.426,-0.645,-0.483,P <0.05),and positively correlated with high density lipoprotein cholesterol (HDL-C) (r =0.453,P <0.01).When SHBG was analyzed as a dependent variable by multiple linear regression,HbA1c (β =-0.614,P =0.000),lgHOMA-IR (β =-0.473,P = 0.014) and HDL-C (β = 0.234,P= 0.048) were into the equation.Conclusions Patients who have diagnosed T2DM show low level of serum SHBG.HOMA-IR and HbA1c are key indicators of SHBG,suggesting that SHBG may be closely related with T2DM.
