Study on depression and level of C-reactive protein in patients with obstructive sleep apnea-hypopnea syndrome
10.3760/cma.j.issn.1673-4904.2011.16.005
- VernacularTitle:阻塞型睡眠呼吸暂停低通气综合征患者抑郁情绪和高敏C反应蛋白的变化
- Author:
Jiabin ZHANG
;
Shukun YANG
;
Qin YU
;
Hongmei YUE
;
Xiaoya WANG
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Sleep apnea,obstructive;
Depression;
Correlation
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(16):12-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of serum high-sensitivity C-reactive protein (ha-CRP) and depression in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS),and investigate the relationship between them.Methods Thirty healthy volunteers (control group) and 54 OSAHS patients (OSAHS group) were recruited for the study.The level of serum hs-CRP was determined by scatter rate nephelometry,and the state of depression was assessed by self-rating depression scale (SDS).Results The level of serum hs-CRP and SDS score were higher in OSAHS group than those in control group [(48.8 ± 12.7) scores vs.(36.3 ± 6.3) scores,(3.3 ±0.7) mg/L vs.(1.4 ± 0.4) mg/L](P＜0.01).SDS score and the level of serum hs-CRPwere positively correlated to apnea-hypopnea index(AHI) (r = 0.636,0.628 ;P<0.01) and negatively related to the MSaO2 (r =-0.509,-0.614;P <0.01) and LSaO2 (r =-0.607,-0.512;P <0.01).The level of serum hs-CRP was positive correlation to SDS score (r = 0.536,P<0.01).SDS score was related to the AHI,the level of serum hs-CRP and LSaO2 in multiple linear regression(F= 33.31,P = 0.002).Conclusion Depression is correlated to AHI and the level of serum hs-CRP in patients with OSAHS.
