Short term effect of gastric bypass surgery for the treatment of nonobese type 2 diabetes mellitus
10.3760/cma.j.issn.1673-9752.2011.03.017
- VernacularTitle:胃转流术治疗非肥胖型2型糖尿病的近期疗效
- Author:
Lijun TANG
;
Tao CHEN
;
Jianfeng GUI
;
Li SHI
;
Hongtao YAN
;
Yunming LI
;
Fuzhou TIAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Gastric bypass surgery;
Nonobese type;
Clinical effect
- From:
Chinese Journal of Digestive Surgery
2011;10(3):214-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short term effect of gastric bypass surgery for the treatment of nonobese type 2 diabetes mellitus and possible mechanisms. Methods The clinical data of 58 patients with nonobese type 2 diabetes mellitus who received gastric bypass surgery from March to August, 2009 were retrospectively analyzed. The levels of fasting plasms glucose (FPG), 2-hour postprandial plasma glucose (2h PG) and glycosylated hemoglobin (HbA1c) were dynamically monitored, and the insulin resistance index (HOMA-IR) and body mass index ( BMI) were calculated. All data were analyzed using variance of analysis and LSD test. Results Of the 58 patients, 48 (83% ) met the requirement of complete response criteria and stopped administration of hypoglycemic agents; 7( 12% ) had to use hypoglycemic agents, but the dose of the agents was lowered by 50% compared to that before surgery. The surgery was ineffective in 3 patients (5% ). The levels of FPG, 2h PG, HbAlc and HOMA-IR of the 58 patients showed a significant decreasing trend after surgery when compared to those before surgery (F = 67. 867, 50. 885, 78. 278, 572. 757, P <0.05), while there was no significant change of the BMI after surgery ( F = 3. 503, P > 0. 05 ). Conclusions Gastric bypass surgery has a good effect on nonobese patients with type 2 diabetes mellitus whose BMI was less than 25 kg/m2. The improvement of insulin resistance after the surgery might be the main reason.
