The effect of recombinant human tissue factor pathway inhibitor-1 on Myocardial infarction in rabbits
10.3760/cma.j.issn.1671-0282.2011.05.017
- VernacularTitle:重组人组织因子途径抑制物-1对兔急性心肌梗死的作用
- Author:
Jingguang LUO
;
Yundai CHEN
;
Yuan Lü
;
Feng TIAN
;
Changhua WANG
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Rabbits;
Extrinsic pathway inhibitor I;
Thromboplastin
- From:
Chinese Journal of Emergency Medicine
2011;20(5):507-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the function of recombinant human tissue factor pathway inhibitor1(rTFPI-1)in acute myocardial infarction in rabbit. Method Forty New Zealand White rabbits were subjected to coronary artery occlusion for 120 min and followed by reperfusion for 60 min,then they were ranlow dose rTFPI-1 group(n=10/group).The extent of ischemic area and the extent of myocardial infarction area were measured by Evan's blue stain and TTC stain,respectively.The degrees of infarction severity and ischemic severity were expressed as the ratios of the total left ventrieular wall area.The degrees of infarction severity and ischemic severity in different groups were compared by using one-way ANOVA and then followed by LSD procedure.Results The degree of infarction severity in the larger dose rTFPI-1 group was significantly lessened than that in low dose RTFPI-1 group and control group(P<0.001),and than that in modcrate dose rTFPI-1 group as well(P<0.05).The degree of infarction severity in the moderate dose rTFPI1 group was significantly lessened than that in low dose rTFPI-1 group and control group(P<0.001).There was no significant difference in degree of infarction severity between low dose rTFPI-1 group and control group(P>0.05).Conclusions Human rTFPI-1 might decrease myocardial infarction severity and save the survival myocardial tissue.
