Wnt signaling pathway and osteosarcoma
10.3760/cma.j.issn.1673-422X.2011.07.023
- VernacularTitle:Wnt信号通路与骨肉瘤
- Author:
Tao KE
;
Xiong AO
;
Zeng HUI
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
Wnt signaling pathway
- From:
Journal of International Oncology
2011;38(7):551-554
- CountryChina
- Language:Chinese
-
Abstract:
The Wnt pathway plays a crucial role in skeletal development and is indispensable for determination of OS cell lines. In recent years, experimental evidences on Wnt signaling pathway in OS cell lines and OS animal models, and that of Wnt signaling pathway as a diagnosis and prognosis marker of OS suggested that Wnt signaling pathway plays an important role in the progression, invasion and metastasis of OS. In addition, the strategy and safety evaluation to target Wnt to treat OS are underway. Exploring the significant role of Wnt signaling pathway in OS may aid in personalizing therapeutics to increase patient survival.
