Hypoxia inducible factor-la and colorectal cancer
10.3760/cma.j.issn.1673-422X.2011.07.022
- VernacularTitle:缺氧诱导因子-1α与结直肠癌
- Author:
Shujun CI
;
Lihong ZHOU
;
Qi LI
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor 1;
alpha subunit;
Colorectal neoplasms
- From:
Journal of International Oncology
2011;38(7):547-550
- CountryChina
- Language:Chinese
-
Abstract:
HIF-1α, a transcriptional activator regulating cells and tissues' response to hypoxia, can induce expression of a variety of factors and facilitate adaptation to hypoxia. Tumor hypoxic microenvironment and expression of HIF-1α is closely related to the occurrence of colorectal cancer, development, invasion, metastasis and prognosis, which becomes a hot spot in colorectal cancer research. To further clarify the process of colorectal cancer and to explore new treatment methods in colorectal cancer, HIF-1α in colorectal cancer studies was briefly reviewed.
