ATM and resistance of gliomas to chemotherapy and radiotherapy
10.3760/cma.j.issn.1673-422X.2011.07.008
- VernacularTitle:DNA损伤检控点ATM与胶质瘤放化疗耐受关系
- Author:
Shiming ZHEN
;
Lijuan YANG
;
Zhixiong LIN
- Publication Type:Journal Article
- Keywords:
DNA damage;
DNA repair;
Glioma;
ATM
- From:
Journal of International Oncology
2011;38(7):506-509
- CountryChina
- Language:Chinese
-
Abstract:
The resistance mechanism of gliomas to chemotherapy and radiotherapy is a complex network of many signaling pathways. It remains unclearhow the pathways interact with each other and how they were regulated. Recent studies have shown that DNA damage checkpoint pathway ( ATM、 ATR、 Chk1、 Chk2、 Rad17、 Radl 、Rad9、Hus1 et al. ) plays an important role in cell proliferation、genomic stability、tumorigenesis and the resistance to chemoradiotherapy of tumors. Inhibiting DNA damage checkpoint can increase tumor sensitivity to chemoradiotherapy and therefore improve the therapeutic effect. We review here the role of ATM in chemoradiotherapy resistance of gliomas and its associated mechanisms.
