Correlation of peptidylarginine deiminase 4 gene polymorphism and colorectal cancer

VernacularTitle:肽基精氨酸脱亚胺酶4基因多态性与、结直肠癌的相关性研究
Author: Kehua FANG ; Jihong PAN ; Xiaotian CHANG
Publication Type:Journal Article
Keywords: Colorectal neoplasms; Genetic predisposition to disease; Polymorphism,single nucleotide
From: Journal of International Oncology 2011;38(6):476-479
CountryChina
Language:Chinese
Abstract: Objective We aim to investigate the association between peptidylarginine deiminase type 4 (PADl4) and colorectal cancer by genotyping threetag single nucleotide polymorphisms (tagSNP) genetic maker, to explore the role of polymorphism of PAD14 gene in development of colorectal cancer. Methods A case-control study was conducted using TaqMan-PCR methods to analyze the genotypes of three TagSNPs such as rs1886302, rs2477131 and rs1635561 for 515 patients with colorectal cancer and 549 health controls. Results There is significantly different in allelic frequencies and genotype frequencies of rs1886302 between cases and controls (P=0.039 and 0.040,respectively). The OR value of A allele and AA genotype is 0.796 and 0.731,respectively,and A allele may reduce the probability of incidence of colorectal cancer. No association Was found among SNPs of rs2477131 and rs1635561 within intronl and intron 15 in terms of coloretal cancer. Conclusion Rs1886302 on PADI4 might be a susceptible SNP to coloretal cancer.