Different expression of promyelocytic leukemia protein in esophageal squamous cell carcinoma and its precursors

VernacularTitle:早幼粒细胞白血病蛋白在食管鳞状细胞癌及癌前病变中的表达与临床意义
Author: Peiqing MA ; Liyan XUE ; Yongqiang XIE ; Guihua SHEN ; Lei GUO ; Ning Lü
Publication Type:Journal Article
Keywords: Cell aging; Esophageal neoplasms; Carcinoma,squamous ceil; Biomarkers
From: Journal of International Oncology 2011;38(6):471-475
CountryChina
Language:Chinese
Abstract: Objective To assess the role of promyelocytic leukemia protein (PML)and P53 in the progression of esophageal squamous cell carcinoma(ESCC)and its precursor lesions. Methods Different expression patterns of PML and P53 of 241 cases of ESCC combined with adjacent precursors were analyzed by tissue array and immunohistochemistry and correlated with clinicopathological parameters. Results In ESCC and its precursor lesions, PML and P53 displayed positive or strong positive, while in normal esophageal epithelia, these proteins showednegative or stained positive only in parabasal cell layer. The expression level of PML was correlated with the depth of invasion of esophageal carcinomas (X2=29.461,P<0.001),lymph metastasis status(X2=15.226,P<0.001)and pTNMs(x2=26.956,P