Correlation between Aurora kinase and tumor
10.3760/cma.j.issn.1673-422X.2011.06.002
- VernacularTitle:Aurora激酶与肿瘤的相关性
- Author:
Yue ZHANG
;
Bin ZHANG
;
Xuchen CAO
- Publication Type:Journal Article
- Keywords:
Aurora kinase;
Neoplasms
- From:
Journal of International Oncology
2011;38(6):406-408
- CountryChina
- Language:Chinese
-
Abstract:
The Aurora kinase family of serine/threonine kinases plays an important role in chromosome alignment,segregation and cytokinesis during mitosis.Overexpression of Aurora kinases has been observed in a variety of human solid tumors and hematological malignancies.Aberrant expression of Aurora kinase can interrupt the function of the checkpoint in mitosis,lead to instability of genetic substance and induce tumorigenesis.
